Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended dilutions.

نویسندگان

  • Udo Kristen
  • Reinhard E Friedrich
چکیده

This study investigated whether mouthwash dilutions, recommended by the manufacturers, may contribute to oral mucosa irritation. Twenty frequently used mouthwash brands were examined by the pollen tube growth test, an alternative in vitro method for assessment of the irritating potential of ingredients of cosmetic formulations. The test is based on the photometric quantification of pollen tube growth inhibition. This parameter is expressed by IC50 values that characterize the cytotoxic potential of a product. The IC50s clearly revealed that none of the tested mouthwashes should cause acute irritation if used in the recommended dilution. However, at least 4 of the mouthwashes evaluated in this study could probably irritate the oral mucosa acutely if used undiluted (original concentration).

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عنوان ژورنال:
  • Brazilian dental journal

دوره 17 1  شماره 

صفحات  -

تاریخ انتشار 2004